Covid-19: US imposes mandatory vaccination on two thirds of workforce

نویسندگان

چکیده

After a 2-hr incubation with soluble immune response suppressor (SIRS), product of concanavalin A-activated murine T cells, macrophages release factor, M phi-derived factor (M phi-SF), which nonspecifically suppresses responses in vitro. The mechanism(s) action phi-SF and range cell types affected by have been investigated. suppressed antibody to background levels if added at culture initiation 80 90% as late 2 hr before assay. Primary secondary IgM IgG responses, proliferative B mitogens, protein secretion, the division several tumor lines were inhibited phi-SF. Division synchronized cells was when any point prior during mitosis; this inhibition could be reversed 2-mercaptoethanol. In presence phi-SF, asynchronous accumulated cycle just released into mitosis These data indicate that inhibits causing block or suggest may general inhibitor cellular proliferation possibly secretion.

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ژورنال

عنوان ژورنال: BMJ

سال: 2021

ISSN: ['0959-8138']

DOI: https://doi.org/10.1136/bmj.n2238